Spleen Macrophages: Population Composition and Functions

被引：1
作者：
Andryukhova E.S. [1 ]
Tashireva L.A. [1 ]
Vtorushin S.V. [1 ,2 ]
Zavyalova M.V. [1 ,2 ]
Perelmuter V.M. [1 ]
机构：
[1] Research Institute of Oncology, Tomsk Research Medical Center, Russian Academy of Sciences, Tomsk
[2] Siberian State Medical University, Ministry of Health of Russia, Tomsk
来源：
Cell and Tissue Biology | 2022年 / 16卷 / 4期
关键词：
carcinomas; macrophages; repair; spleen; splenectomy;
D O I：
10.1134/S1990519X22040034
中图分类号：
学科分类号：
摘要：
Abstract: The heterogeneous population of macrophages in the spleen perform a variety of important functions. Studies of spleen macrophages have mostly been carried out in experimental models. Much remains unexplored. This review summarizes data on the characteristics of macrophages in different functional areas of the spleen in human beings and animals. The role of spleen macrophages in the utilization of senescent erythrocytes, iron metabolism, immunogenesis, immunosuppression, elimination of cells in the state of apoptosis, phagocytosis of hematogenous spread pathogens and the participation of tuftsin in this process, as well as the spleen role as a reservoir of monocytes involved in inflammation and regeneration are discussed. It was attempted to find data on the possible role of spleen macrophages in the rare occurrence of metastatic lesions in this organ. Some important but poorly studied functional aspects of human and animal spleen macrophages are discussed. © 2022, Pleiades Publishing, Ltd.
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页码：291 / 301
页数：10
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