Use of procalcitonin in the diagnosis of tuberculosis in infants and preschool children

被引：0
作者：
Eneritz Velasco-Arnaiz
Esther Pérez
Desirée Henares
Anna Fernández-López
Anna Valls
Pedro Brotons
Clàudia Fortuny
Antoni Noguera-Julian
机构：
[1] Institut de Recerca Pediàtrica Hospital Sant Joan de Déu,Malalties infeccioses i resposta inflamatòria sistèmica en pediatria, Unitat d’Infeccions, Servei de Pediatria
[2] Hospital Sant Joan de Déu,Institut de Recerca Pediàtrica
[3] Hospital Sant Joan de Déu,Laboratory Department
[4] CIBER de Epidemiología y Salud Pública (Ciberesp),Departament de Pediatria
[5] Universitat de Barcelona,undefined
[6] Traslational Research Network in Pediatric Infectious Diseases (RITIP),undefined
来源：
European Journal of Pediatrics | 2018年 / 177卷
关键词：
C-reactive protein; Erythrocyte sedimentation rate; Pneumonia; Procalcitonin; Tuberculosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Normal procalcitonin (PCT) levels have been reported in adult pulmonary tuberculosis (TB) but have not been previously investigated in children. We aimed to assess PCT levels at diagnosis of TB in young children in a low-burden setting. In a cross-sectional observational study in a referral pediatric center in Barcelona (Spain), we assessed the value of PCT and other inflammatory markers (leucocyte counts, C-reactive protein, and erythrocyte sedimentation rate) in the diagnosis of TB in pre-school children (< 6 years at diagnosis, n = 45), as compared with two control groups (pneumococcal pneumonia, n = 25; and healthy controls, n = 49). Normal PCT levels were observed at diagnosis of TB in most cases, while C-reactive protein values and leucocyte counts were slightly elevated when compared to healthy controls. All three inflammatory biomarkers were significantly higher in children with pneumococcal pneumonia.
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页码：1377 / 1381
页数：4
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  • [1] Davies J(2015)Procalcitonin J Clin Pathol 368 675-679
  • [2] Díez-Padrisa N(2010)Procalcitonin and C-reactive protein for invasive bacterial pneumonia diagnosis among children in Mozambique, a malaria-endemic area PLoS One 5 1175-1179
  • [3] Bassat Q(2013)Elevated inflammatory markers combined with positive pneumococcal urinary antigen are a good predictor of pneumococcal community-acquired pneumonia in children Pediatr Infect Dis J 32 215-218
  • [4] Machevo S(2015)Procalcitonin and community-acquired pneumonia (CAP) in children Clin Chim Acta 451 S199-2208
  • [5] Quintó L(2012)Evaluation of tuberculosis diagnostics in children: 1. Proposed clinical case definitions for classification of intrathoracic tuberculosis disease Consensus from an expert panel J Infect Dis 205 470-477
  • [6] Morais L(2014)Value of procalcitonin in differentiating pulmonary tuberculosis from other pulmonary infections: a meta-analysis Int J Tuberc Lung Dis 18 440-447
  • [7] Nhampossa T(2014)High serum levels of procalcitonin and soluble TREM-1 correlated with poor prognosis in pulmonary tuberculosis J Inf Secur 68 510-515
  • [8] O'Callaghan-Gordo C(2006)Serum procalcitonin distinguishes CAP due to bacteria, mycobacterium tuberculosis and PJP Int J Tuberc Lung Dis 10 235-243
  • [9] Torres A(2015)Tuberculosis as a cause or comorbidity of childhood pneumonia in tuberculosis-endemic areas: a systematic review Lancet Respir Med 3 292-298
  • [10] Alonso PL(2014)Use of procalcitonin for the prediction and treatment of acute bacterial infection in children Curr Opin Pediatr 26 371-375
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