Molecular characterization of the surface glycoprotein genes of highly pathogenic H5N1 avian influenza viruses detected in Iran in 2011

被引：0
作者：
Ebrahim Kord
Amir Kaffashi
Hadi Ghadakchi
Fatemeh Eshratabadi
Zakaria Bameri
Abdelhamed Shoushtari
机构：
[1] Razi Vaccine and Serum Research Institute,
来源：
Tropical Animal Health and Production | 2014年 / 46卷
关键词：
Influenza; Avian influenza; H5N1; Highly Pathogenic Avian Influenza (HPAI);
D O I：
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中图分类号：
学科分类号：
摘要：
Highly pathogenic avian influenza (HPAI) H5N1 virus is causing the death of a large number of wild birds and poultry. HPAI H5N1 was reported in the north of Iran in 2011. In this study, two A/Chicken/Iran/271/2011 and A/Duck/Iran/178/2011 viruses were genetically characterized by sequence analysis of Hemagglutinin (HA) and Neuraminidase (NA) genes. Phylogenetic analysis revealed that these viruses were different from previous Iranian isolates (Clade 2.2) and belonged to the subclade 2.3.2.1. The results showed that the detected viruses are almost identical to each other and closely related to HPAI H5N1 strains isolated in Mongolia in 2010. Based on the amino acid sequence analysis, these viruses at their HA cleavage sites contained the multibasic amino acid motif PQRERRRK-R/GLF lacking a lysine residue compared with the previous reports of the same motif. There is also a 20-amino acid deletion (resides 49–69) in the NA stalk similar to other viruses isolated after 2000. It seems that introduction of HPAI H5N1 to Iran might have happened by wild birds from Mongolian origin virus.
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页码：549 / 554
页数：5
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[1]  
Baigent SJ(2001)Glycosylation of haemagglutinin and stalk-length of neuraminidase combine to regulate the growth of avian influenza viruses in tissue culture Virus research 79 177-185
[2]  
McCauley JW(2010)Highly pathogenic H5N1 influenza viruses carry virulence determinants beyond the polybasic hemagglutinin cleavage site PLoS One 5 e11826-193
[3]  
Bogs J(2010)Summary of avian influenza activity in Europe, Asia, and Africa, 2006-2009 Avian diseases 54 187-6
[4]  
Veits J(2002)Avian influenza and human health Acta tropica 83 1-1363
[5]  
Gohrbandt S(2009)H5N1 Virus Evolution in Europe—An Updated Overview Viruses 1 1351-13
[6]  
Hundt J(2011)The ecology of influenza A viruses in wild birds in southern Africa EcoHealth 8 4-E1422
[7]  
Stech O(2011)Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy Proceedings of the National Academy of Sciences 108 E1417-2672
[8]  
Breithaupt A(2005)Oseltamivir resistance during treatment of influenza A (H5N1) infection New England Journal of Medicine 353 2667-173
[9]  
Teifke JP(2012)Avian influenza and the implication for human infection Microbiology 33 172-1757
[10]  
Mettenleiter TC(2010)Avian influenza virus monitoring in wintering waterbirds in Iran, 2003-2007 Virol J 7 1754-19
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