MicroRNAs-mediated regulation pathways in rheumatic diseases

被引:0
|
作者
Sara Assadiasl
Misagh Rajabinejad
Narjes Soleimanifar
Farideh Makiyan
Esfandiar Azizi
Alireza Rezaiemanesh
Mohammad Hossein Nicknam
机构
[1] Tehran University of Medical Sciences,Molecular Immunology Research Center
[2] Mazandaran University of Medical Sciences,Student Research Committee, School of Medicine
[3] Mazandaran University of Medical Sciences,Department of Immunology, School of Medicine
[4] University of Tehran,Division of Nanobiotechnology, Department of Life Sciences Engineering, Faculty of New Sciences and Technologies
[5] Ilam University of Medical Sciences,Department of Immunology, Faculty of Medicine
[6] Kermanshah University of Medical Sciences,Department of Immunology, School of Medicine
来源
Inflammopharmacology | 2023年 / 31卷
关键词
Rheumatic disorders; Rheumatoid arthritis; Ankylosing spondylitis; MicroRNA; Signaling pathways;
D O I
暂无
中图分类号
学科分类号
摘要
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are two common rheumatic disorders marked by persistent inflammatory joint disease. Patients with RA have osteodestructive symptoms, but those with AS have osteoproliferative manifestations. Ligaments, joints, tendons, bones, and muscles are all affected by rheumatic disorders. In recent years, many epigenetic factors contributing to the pathogenesis of rheumatoid disorders have been studied. MicroRNAs (miRNAs) are small, non-coding RNA molecules implicated as potential therapeutic targets or biomarkers in rheumatic diseases. MiRNAs play a critical role in the modulation of bone homeostasis and joint remodeling by controlling fibroblast-like synoviocytes (FLSs), chondrocytes, and osteocytes. Several miRNAs have been shown to be dysregulated in rheumatic diseases, including miR-10a, 16, 17, 18a, 19, 20a, 21, 27a, 29a, 34a, 103a, 125b, 132, 137, 143, 145, 146a, 155, 192, 203, 221, 222, 301a, 346, and 548a.The major molecular pathways governed by miRNAs in these cells are Wnt, bone-morphogenic protein (BMP), nuclear factor (NF)-κB, receptor activator of NF-κB (RANK)—RANK ligand (RANKL), and macrophage colony-stimulating factor (M-CSF) receptor pathway. This review aimed to provide an overview of the most important signaling pathways controlled by miRNAs in rheumatic diseases.
引用
收藏
页码:129 / 144
页数:15
相关论文
共 50 条
  • [1] MicroRNAs-mediated regulation pathways in rheumatic diseases
    Assadiasl, Sara
    Rajabinejad, Misagh
    Soleimanifar, Narjes
    Makiyan, Farideh
    Azizi, Esfandiar
    Rezaiemanesh, Alireza
    Nicknam, Mohammad Hossein
    INFLAMMOPHARMACOLOGY, 2023, 31 (01) : 129 - 144
  • [2] MicroRNA-mediated immune regulation in rheumatic diseases
    Lam, Ian Kar Yin
    Chow, Jia Xin
    Lau, Chak Sing
    Chan, Vera Sau Fong
    CANCER LETTERS, 2018, 431 : 201 - 212
  • [3] MicroRNAs-mediated cell fate in triple negative breast cancers
    Sui, Xinbing
    Wang, Xian
    Han, Weidong
    Li, Da
    Xu, Yinghua
    Lou, Fang
    Zhou, Jichun
    Gu, Xidong
    Zhu, Jing
    Zhang, Cheng
    Pan, Hongming
    CANCER LETTERS, 2015, 361 (01) : 8 - 12
  • [4] MicroRNAs in systemic rheumatic diseases
    Angela Ceribelli
    Bing Yao
    Paul R Dominguez-Gutierrez
    Md A Nahid
    Minoru Satoh
    Edward KL Chan
    Arthritis Research & Therapy, 13
  • [5] Regulation of TLR signaling pathways by microRNAs: implications in inflammatory diseases
    Arenas-Padilla, Marina
    Mata-Haro, Veronica
    CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY, 2018, 43 (04) : 482 - 489
  • [6] MicroRNAs-mediated regulation of the differentiation of dental pulp-derived mesenchymal stem cells: a systematic review and bioinformatic analysis
    Iranmanesh, Pedram
    Vedaei, Amirhossein
    Salehi-Mazandarani, Sadra
    Nikpour, Parvaneh
    Khazaei, Saber
    Khademi, Abbasali
    Galler, Kerstin M. M.
    Nekoofar, Mohammad-Hossein
    Dummer, Paul M. H.
    STEM CELL RESEARCH & THERAPY, 2023, 14 (01)
  • [7] MicroRNAs-mediated regulation of the differentiation of dental pulp-derived mesenchymal stem cells: a systematic review and bioinformatic analysis
    Pedram Iranmanesh
    Amirhossein Vedaei
    Sadra Salehi-Mazandarani
    Parvaneh Nikpour
    Saber Khazaei
    Abbasali Khademi
    Kerstin M. Galler
    Mohammad-Hossein Nekoofar
    Paul M. H. Dummer
    Stem Cell Research & Therapy, 14
  • [8] The role of microRNAs in diseases and related signaling pathways
    Atena Vaghf
    Behzad Khansarinejad
    Ehsanollah Ghaznavi-Rad
    Mahdieh Mondanizadeh
    Molecular Biology Reports, 2022, 49 : 6789 - 6801
  • [9] The role of microRNAs in diseases and related signaling pathways
    Vaghf, Atena
    Khansarinejad, Behzad
    Ghaznavi-Rad, Ehsanollah
    Mondanizadeh, Mahdieh
    MOLECULAR BIOLOGY REPORTS, 2022, 49 (07) : 6789 - 6801
  • [10] MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia
    Chakraborty, Chiranjib
    Sharma, Ashish Ranjan
    Patra, Bidhan Chandra
    Bhattacharya, Manojit
    Sharma, Garima
    Lee, Sang-Soo
    ONCOTARGET, 2016, 7 (27) : 42683 - 42697