Extracellular Vesicles: the Next Frontier in Pregnancy Research

被引：0

作者：

Ali Afzal

Madeeha Khan

Zaman Gul

Rameen Asif

Sara Shahzaman

Asia Parveen

Muhammad Imran

Muhammad Babar Khawar

机构：

[1] University of Central Punjab,Molecular Medicine and Cancer Therapeutics Lab, Department of Zoology, Faculty of Science and Technology

[2] College of Allied Health Sciences,Department of Zoology

[3] Akhtar Saeed Medical and Dental College,Center for Applied Molecular Biology

[4] Institute of Zoology,Applied Molecular Biology & Biomedicine Lab, Department of Zoology

[5] University of the Punjab,undefined

[6] Government College University,undefined

[7] University of the Punjab,undefined

[8] Institute of Translational Medicine,undefined

[9] Medical College,undefined

[10] Yangzhou University,undefined

[11] University of Narowal,undefined

来源：

Reproductive Sciences | 2024年 / 31卷

关键词：

Extracellular vesicles; Pregnancy; Preeclampsia; Gestational diabetes mellitus; Preterm labor;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Extracellular vehicles (EVs) have been involved in several aspects of pregnancy, including endometrial receptivity, embryo implantation, and embryo-maternal communication showing them associated with pregnancy disorders, such as preeclampsia, gestational diabetes mellitus, and preterm birth. Further research is warranted to fully comprehend the exact pathophysiological roles of EVs and to develop new therapies targeting EVs thereby improving pregnancy outcomes. Herein, we review the recent knowledge on the multifaceted roles of EVs during pregnancy and address the majority of the molecular interactions between EVs, maternal, and fetal cells with an emphasis on disorders of pregnancy under the influence of EVs. Moreover, we also discuss its applications in clinical trials followed by prospects.

引用

页码：1204 / 1214

页数：10

共 451 条

[61]

Kale V(2023)Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth Reproduction. 165 R9-undefined

[62]

Shekibi M(2020)Risk factors associated with preterm labor, with special emphasis on preterm premature rupture of membranes and severe preterm labor J Chin Med Assoc 83 280-undefined

[63]

Heng S(2018)Extracellular vesicle RNA s reflect placenta dysfunction and are a biomarker source for preterm labour J Cell Mol Med 22 2760-undefined

[64]

Nie G(2018)Placental exosomes during gestation: liquid biopsies carrying signals for the regulation of human parturition Curr Pharm Des 24 974-undefined

[65]

Gurung S(2019)Circulating exosomal miRNA profile during term and preterm birth pregnancies: a longitudinal study Endocrinology. 160 249-undefined

[66]

Greening DW(2019)First trimester circulating microRNA biomarkers predictive of subsequent preterm delivery and cervical shortening Sci Rep 9 1-undefined

[67]

Catt S(2018)Amnion epithelial cell–derived exosomes induce inflammatory changes in uterine cells Am J Obstet Gynecol 219 478-undefined

[68]

Salamonsen L(2019)Extracellular vesicles in cancer immune microenvironment and cancer immunotherapy Adv Sci 6 1901779-undefined

[69]

Evans J(2019)Exosome-mediated metastasis: communication from a distance Dev Cell 49 347-undefined

[70]

Evans J(2021)Extracellular vesicles as biomarkers and therapeutic tools: from pre-clinical to clinical applications Biology. 10 359-undefined

← 2 3 4 5 6 7 8 9 10 11 →