The role of STAT3 in tumor-mediated immune suppression

被引:0
作者
Sherise D. Ferguson
Visish M. Srinivasan
Amy B. Heimberger
机构
[1] The University of Texas M. D. Anderson Cancer Center,Department of Neurosurgery
来源
Journal of Neuro-Oncology | 2015年 / 123卷
关键词
STAT3; Glioblastoma; Immune suppression;
D O I
暂无
中图分类号
学科分类号
摘要
The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.
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页码:385 / 394
页数:9
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