DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome

被引：0
|
作者：
Pooja Sagvekar
Pankaj Kumar
Vijay Mangoli
Sadhana Desai
Srabani Mukherjee
机构：
[1] ICMR-National Institute for Research in Reproductive Health,Department of Molecular Endocrinology
[2] National Centre for Biological Sciences (NCBS),Colin Jamura Lab, Institute for Stem Cell Biology and Regenerative Medicine (inStem)
[3] Fertility Clinic and IVF Center,undefined
来源：
Clinical Epigenetics | 2019年 / 11卷
关键词：
PCOS; Methylome profiling; DNA methylation; IVF; Granulosa cells; NGS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Endocrine Disrupting Chemicals in Polycystic Ovary Syndrome: The Relevant Role of the Theca and Granulosa Cells in the Pathogenesis of the Ovarian Dysfunction
    Jozkowiak, Malgorzata
    Piotrowska-Kempisty, Hanna
    Kobylarek, Dominik
    Gorska, Natalia
    Mozdziak, Paul
    Kempisty, Bartosz
    Rachon, Dominik
    Spaczynski, Robert Z.
    CELLS, 2023, 12 (01)
  • [22] High-Throughput Sequencing Profiles About lncRNAs and mRNAs of Ovarian Granulosa Cells in Polycystic Ovary Syndrome
    Zheng, Yanjun
    Bian, Yuehong
    Wu, Richao
    Chen, Wei
    Fu, Linlin
    Li, Ping
    Wang, Ying
    Yang, Xiao
    Zhao, Shigang
    Shi, Yuhua
    FRONTIERS IN MEDICINE, 2021, 8
  • [23] A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells
    Qu, Fan
    Wang, Fang-Fang
    Yin, Rong
    Ding, Guo-Lian
    El-prince, Mohamed
    Gao, Qian
    Shi, Bi-Wei
    Pan, Hui-Hui
    Huang, Yi-Ting
    Jin, Min
    Leung, Peter C. K.
    Sheng, Jian-Zhong
    Huang, He-Feng
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2012, 90 (08): : 911 - 923
  • [24] Elevated SAA1 promotes the development of insulin resistance in ovarian granulosa cells in polycystic ovary syndrome
    Zhu, Qinling
    Yao, Yue
    Xu, Lizhen
    Wu, Hasiximuke
    Wang, Wangsheng
    He, Yaqiong
    Wang, Yuan
    Lu, Yao
    Qi, Jia
    Ding, Ying
    Li, Xinyu
    Huang, Jiaan
    Zhao, Hanting
    Du, Yanzhi
    Sun, Kang
    Sun, Yun
    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2022, 20 (01)
  • [25] Expression of polycystic ovary syndrome candidate genes in bovine fetal and adult ovarian somatic cells
    Liu, Menghe
    Hummitzsch, Katja
    Bastian, Nicole A.
    Hartanti, Monica D.
    Irving-Rodgers, Helen F.
    Anderson, Richard A.
    Rodgers, Raymond Joseph
    REPRODUCTION AND FERTILITY, 2022, 3 (04): : 273 - 286
  • [26] Dysregulation of ferroptosis-related genes in granulosa cells associates with impaired oocyte quality in polycystic ovary syndrome
    Huang, Jialyu
    Fan, Hancheng
    Li, Chenxi
    Yang, Kangping
    Xiong, Chaoyi
    Xiong, Siyi
    Feng, Shenghui
    Chen, Shen
    Wang, Bangqi
    Su, Yufang
    Xu, Boyun
    Yang, Haiyan
    Wang, Ni
    Zhu, Jing
    FRONTIERS IN ENDOCRINOLOGY, 2024, 15
  • [27] Downregulation of CASC15 attenuates the symptoms of polycystic ovary syndrome by affecting granulosa cell proliferation and regulating ovarian follicular development
    Zhang, Tongwei
    Fang, Junnan
    Hu, Jingyi
    Kong, Yue
    Jiang, Ran
    Wang, Huihui
    Yang, Guang
    Yao, Guidong
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2024, 592
  • [28] Protein Lysine Acetylation in Ovarian Granulosa Cells Affects Metabolic Homeostasis and Clinical Presentations of Women With Polycystic Ovary Syndrome
    Min, Zheying
    Long, Xiaoyu
    Zhao, Hongcui
    Zhen, Xiumei
    Li, Rong
    Li, Mo
    Fan, Yong
    Yu, Yang
    Zhao, Yue
    Qiao, Jie
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
  • [29] The upregulation of 11β-HSD1 in ovarian granulosa cells by cortisol and interleukin-1β in polycystic ovary syndrome
    Wu, Hasiximuke
    Zhu, Qinling
    Li, Xinyu
    He, Yaqiong
    Wang, Yuan
    Lu, Yao
    Qi, Jia
    Ding, Ying
    Li, Jiaxing
    Xu, Rui
    Sun, Yun
    GYNECOLOGICAL ENDOCRINOLOGY, 2020, 36 (08) : 668 - 672
  • [30] Akt-mTOR Signaling Mediates Abnormalities in the Proliferation and Apoptosis of Ovarian Granulosa Cells in Patients with Polycystic Ovary Syndrome
    Song, Wan-Juan
    Shi, Xiaobo
    Zhang, Jing
    Chen, Luo
    Fu, Shu-Xin
    Ding, Yi-Ling
    GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2018, 83 (02) : 124 - 132
12345