Pregnancy-associated plasma protein-A and asthma

被引：0
作者：
Abdurrahman Coskun
Oner Balbay
Sadik Duran
Ali Nihat Annakkaya
Ismet Bulut
Ozlem Yavuz
Emel Kurt
机构：
[1] Duzce University,Department of Clinical Biochemistry
[2] School of Medicine,Department of Pulmonary Medicine
[3] Osman Gazi University School of Medicine,undefined
[4] Department of Cardiology,undefined
来源：
Advances in Therapy | 2007年 / 24卷
关键词：
asthma; atherosclerosis; IGF; IGFBP-4; PAPP-A;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pregnancy-associated plasma protein-A (PAPP-A) is potentially a proatherosclerotic metalloproteinase and a new inflammatory marker. Investigators sought to evaluate the significance of PAPP-A in patients with asthma. Blood samples were collected from 35 patients and 20 control subjects. Serum PAPP-A was determined by enzyme-linked immunosorbent assay. PAPP-A levels of patients with asthma (8.1±5.0 mU/L) were higher than those of the control group (4.9±2.1 mU/L) (P < .01). A significant correlation was noted between serum PAPP-A concentration and asthma severity (r=.581;P < .01). Investigators concluded that PAPP-A may contribute to airway smooth muscle hyperplasia as an insulin-like growth factor-dependent insulin-like growth factor-binding protein-4 protease in patients with asthma.
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页码：362 / 367
页数：5
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