Isoniazid derivatization strategy of carboxyl-containing metabolites for LC-MS/MS-based targeted metabolomics

[1] Newgard CB(2016)Metabolomics and metabolic diseases: where do we stand? Cell Metab 25 43-56

[2] Zhao S(2019)Metabolomic coverage of chemical-group-submetabolome analysis: group classification and four-channel chemical isotope labeling LC-MS Anal Chem 91 12108-12115

[3] Li H(2021)Simultaneous 3-nitrophenylhydrazine derivatization strategy of carbonyl, carboxyl and phosphoryl submetabolome for LC-MS/MS-based targeted metabolomics with improved sensitivity and coverage Anal Chem 93 10075-10083

[4] Han W(2015)Serially coupling hydrophobic interaction and reversed-phase chromatography with simultaneous gradients provides greater coverage of the metabolome Metabolomics 11 1465-1470

[5] Chan W(2016)Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease Nutr Rev 74 624-634

[6] Li L(2019)Mass spectrometry-based metabolomics: targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders Mass Spectrom Rev 38 22-33

[7] Meng XJ(2021)Phenylalanine metabolism is dysregulated in human hippocampus with Alzheimer’s disease related pathological changes J Alzheimers Dis 83 609-622

[8] Pang HH(2018)Polarity-tuning derivatization-LC-MS approach for probing global carboxyl-containing metabolites in colorectal cancer Anal Chem 90 11210-11215

[9] Sun F(2011)Structure and biological activities of the polysaccharides from the leaves, roots and fruits of Panax ginseng C. A. Meyer: An overview Carbohyd Polym 85 490-499

[10] Jin XH(2019)Pharmacodynamic and urinary metabolomics studies on the mechanism of Schisandra polysaccharide in the treatment of Alzheimer’s disease Food Funct 10 432-447

[1] Newgard CB(2016)Metabolomics and metabolic diseases: where do we stand? Cell Metab 25 43-56

[2] Zhao S(2019)Metabolomic coverage of chemical-group-submetabolome analysis: group classification and four-channel chemical isotope labeling LC-MS Anal Chem 91 12108-12115

[3] Li H(2021)Simultaneous 3-nitrophenylhydrazine derivatization strategy of carbonyl, carboxyl and phosphoryl submetabolome for LC-MS/MS-based targeted metabolomics with improved sensitivity and coverage Anal Chem 93 10075-10083

[4] Han W(2015)Serially coupling hydrophobic interaction and reversed-phase chromatography with simultaneous gradients provides greater coverage of the metabolome Metabolomics 11 1465-1470

[5] Chan W(2016)Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease Nutr Rev 74 624-634

[6] Li L(2019)Mass spectrometry-based metabolomics: targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders Mass Spectrom Rev 38 22-33

[7] Meng XJ(2021)Phenylalanine metabolism is dysregulated in human hippocampus with Alzheimer’s disease related pathological changes J Alzheimers Dis 83 609-622

[8] Pang HH(2018)Polarity-tuning derivatization-LC-MS approach for probing global carboxyl-containing metabolites in colorectal cancer Anal Chem 90 11210-11215

[9] Sun F(2011)Structure and biological activities of the polysaccharides from the leaves, roots and fruits of Panax ginseng C. A. Meyer: An overview Carbohyd Polym 85 490-499

[10] Jin XH(2019)Pharmacodynamic and urinary metabolomics studies on the mechanism of Schisandra polysaccharide in the treatment of Alzheimer’s disease Food Funct 10 432-447