Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation

被引：0
作者：
C. S. Ananda Kumar
S. Nanjunda Swamy
N. R. Thimmegowda
S. B. Benaka Prasad
George W. Yip
K. S. Rangappa
机构：
[1] University of Mysore,Department of Studies in Chemistry
[2] National University of Singapore,Department of Anatomy
[3] University of Mysore,DOS in Chemistry
来源：
Medicinal Chemistry Research | 2007年 / 16卷
关键词：
1-benzhydryl-piperazine derivatives; Sulfonyl chlorides; MDA-MB-231; Cell proliferation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of novel 1-benzhydryl-sulfonyl-piperazine derivatives 7(a-e) were designed by a nucleophilic substitution reaction of 1-benzhydryl-piperazine with various sulfonyl chlorides and characterized by 1H nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry (LC/MS), Fourier-transform infrared (FTIR), and elemental analysis. Our research is focused on identifying synthetically occurring chemotherapeutic substances capable of inhibiting, retarding, or reversing the process of multistage carcinogenesis. The title compounds were evaluated for their efficacy in inhibiting MDA-MB-231 breast cancer cell proliferation. Compound 1-benzhydryl-4-(4-tert-butyl-benzenesulfonyl)-piperazine (7d) showed significant inhibitory activity.
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页码：179 / 187
页数：8
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