Synthesis and Antibacterial Activity of Hybrid Supramolecular Complexes Based on Tetracycline/Doxycycline and Water-Soluble C60-Fullerene Derivatives

被引：0
作者：
A. V. Zhilenkov
E. A. Khakina
P. A. Troshin
K. S. Inchagova
D. G. Deryabin
机构：
[1] Russian Academy of Sciences,Institute for Problems of Chemical Physics
[2] Skolkova Institute of Science and Technology,undefined
[3] All-Russian Research Institute of Cattle Breeding,undefined
[4] Orenburg State University,undefined
来源：
Pharmaceutical Chemistry Journal | 2017年 / 50卷
关键词：
tetracycline; C60-fullerene; hybrid complex; antibacterial activity;
D O I：
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中图分类号：
学科分类号：
摘要：
Water-soluble pentasubstituted anionic and cationic C60-fullerene derivatives were synthesized in highly selective reactions of chlorofullerene C60Cl6 with captopril and an aliphatic amine. Hybrid supramolecular complexes of the functionalized C60-fullerene derivatives and tetracycline antibiotics (in a stoichiometric 1:1 mole ratio) with polymodal hydrodynamic-radius distributions were synthesized in aqueous solution as nano-sized micelles and vesicles. Hybrid complexes of the antibiotics and cationic amino-C60-fullerene derivatives exhibited synergic antibacterial effects that were more pronounced against a tetracycline-resistant Escherichia coli strain (carrier of the TcR gene).
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页码：637 / 641
页数：4
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