DNA flow-cytometric, histological and hormonal analysis of sertoli cell only syndrome (SECOS)

被引：5

作者：

Kostakopoulos A. ^{[1
]}

Protoyerou V. ^{[1
]}

Tekerlekis P. ^{[1
]}

Georgoulakis J. ^{[1
]}

Louras G. ^{[1
]}

Goulandris N. ^{[1
]}

机构：

[1] Department of Urology, University of Athens, Sismanoglio Hospital, Athens

来源：

International Urology and Nephrology | 2002年 / 33卷 / 1期

关键词：

Public Health; Histological Examination; Cell Damage; Hormonal Level; Histological Finding;

D O I：

10.1023/A:1014417322540

中图分类号：

学科分类号：

摘要：

Sertoli cell only syndrome (SECOS) was identified on histology in 21 cases (16,28%) among 129 testicular biopsies performed in our department for azoospermia over the last 5 years. In these patients history, clinical features, hormonal levels, and histological findings were analyzed. In addition DNA flow-cytometric analysis was performed and showed an almost complete absence of haploid cells. All patients presented with elevated serum FSH levels suggesting a Sertoli cell damage or reduced production of inhibin due to the absence of sermatogenic cells. An good correlation was found between histological findings and DNA histograms. In conclusion SECOS is a syndrome of unknown aetiology presenting in men with azoospermia. DNA flow-cytometric analysis is a reliable, rapid and easy method in the diagnosis of SECOS, and can replace histological examination.

引用

页码：77 / 79

页数：2

共 7 条

[1]

Rothman C.M., Sims C.A., Stotts C.L., Sertoli only syndrome, Fertil Steril, 38, pp. 388-390, (1982)

[2]

Hirsch I.H., McCue P., Kulp-Hughes D., Sedor J., Flanigan M., Validation of flow cytometry analysis in the objective assessment of spermatogenesis: Comparison to the quantitative testicular biopsy, J Urol, 150, pp. 342-346, (1993)

[3]

Clausen O.P.F., Abyholm T., Deoxyribonucleic acid flow cytometry of germ cells in the investigation of male infertility, Fertil Steril, 343, pp. 369-372, (1980)

[4]

Kostakopoulos A., Georgoulakis J., Deliveliotis C.H., Spanakis G., Fillipidou A., Tamvakis N., DNA flow-cytometric analysis in the assessment of serpmatogenesis, J Urol, 158, pp. 79-81, (1997)

[5]

Talati J., Sheikh H., Sertoli cell only syndrome (SECOS): Lessons from case studies, JPMA, 219, pp. 223-226, (1991)

[6]

Ishida H., Iasirugi K., Aso V., Takayami H., Tamsoki B., Endocrine studies in Sertoli cell only syndrome, J Urol, 116, pp. 56-58, (1976)

[7]

Wong T.W., Straus F.H., Warner N.E., Testicular biopsy in the study of male infertility, Arch Pathol, 95, pp. 151-154, (1973)

← 1 →