Quantitative Proteomic Analysis of Human Substantia Nigra in Alzheimer’s Disease, Huntington’s Disease and Multiple Sclerosis

被引：0
作者：
Sheng Chen
Frances Fangjia Lu
Philip Seeman
Fang Liu
机构：
[1] Centre for Addiction and Mental Health,Department of Molecular Neuroscience
[2] University of Toronto,Department of Pharmacology
来源：
Neurochemical Research | 2012年 / 37卷
关键词：
Substantia nigra; Quantitative proteomics; Alzheimer’s disease; Huntington’s disease; Multiple sclerosis;
D O I：
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中图分类号：
学科分类号：
摘要：
The substantia nigra plays important roles in the brain function and is critical in the development of many diseases, particularly Parkinson’s disease. Pathological changes of the substantia nigra have also been reported in other neurodegenerative diseases. Using a quantitative proteomic approach, we investigated protein expressions in the substantia nigra of Alzheimer’s disease, Huntington’s disease, and Multiple sclerosis. The expression level of one hundred and four proteins that were identified in at least three samples of each group were compared with the control group, with nineteen, twenty-two and thirteen proteins differentially expressed in Alzheimer’s diseases, Huntington’s disease and Multiple sclerosis respectively. The result indicates that the substantia nigra also undergoes functional adaption or damage in these diseases.
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页码：2805 / 2813
页数：8
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