Adverse effects of small-volume red blood cell transfusions in the neonatal population

被引：5
作者：
Keir A. [1 ,2 ]
Pal S. [3 ]
Trivella M. [4 ]
Lieberman L. [5 ,6 ]
Callum J. [7 ,8 ]
Shehata N. [8 ,9 ]
Stanworth S. [10 ]
机构：
[1] School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide
[2] Department of Neonatal Medicine, Women's and Children's Hospital, Level 1 Queen Victoria Building, 72 King William Road, North Adelaide, 5006, SA
[3] Rosie Neonatal Unit, Cambridge University Hospitals NHS Foundation Trust Cambridge, Cambridge
[4] Centre for Statistics in Medicine, University of Oxford, Oxford
[5] Transfusion Medicine, University Health Network, Toronto
[6] Department of Clinical Pathology, University of Toronto, Toronto
[7] Transfusion Medicine and Tissue Banks, Sunnybrook Health Sciences Centre, Toronto
[8] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto
[9] Department of Medicine, Mount Sinai Hospital, Toronto
[10] National Health Service Blood, Transplant/Oxford University Hospitals NHS Trust, Oxford
来源：
Systematic Reviews | / 3卷 / 1期
关键词：
Neonates; Red blood cell transfusion; Systematic review; Transfusion reaction; Transfusion/adverse effects;
D O I：
10.1186/2046-4053-3-92
中图分类号：
学科分类号：
摘要：
Background: Adverse transfusion reactions in the neonatal population are poorly understood and defined. The incidence and pattern of adverse effects due to red blood cell (RBC) transfusion are not well known, and there has been no systematic review of published adverse events. RBC transfusions continue to be linked to the development of morbidities unique to neonates, including chronic lung disease, retinopathy of prematurity, intraventricular haemorrhage and necrotising enterocolitis. Uncertainties about the exact nature of risks alongside benefits of RBC transfusion may contribute to evidence of widespread variation in neonatal RBC transfusion practice. Our review aims to describe clinical adverse effects attributed to small-volume (10-20 mL/kg) RBC transfusions and, where possible, their incidence rates in the neonatal population through the systematic identification of all relevant studies. Methods: A comprehensive search of the following bibliographic databases will be performed: MEDLINE (PubMed/OVID which includes the Cochrane Library) and EMBASE (OVID). The intervention of interest is small-volume (10-20 mL/kg) RBC transfusions in the neonatal population. We will undertake a narrative synthesis of the evidence. If clinical similarity and data quantity and quality permit, we will also carry out meta-analyses on the listed outcomes. Discussion: This systematic review will identify and synthesise the reported adverse effects and associations of RBC transfusions in the neonatal population. We believe that this systematic review is timely and will make a valuable contribution to highlight an existing research gap. © 2014 Keir et al.; licensee BioMed Central Ltd.
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  • [1] Strauss R.G., Anaemia of prematurity: pathophysiology and treatment, Blood Rev, 24, pp. 221-225, (2010)
  • [2] Strauss R.G., Levy G.J., Sotelo-Avila C., Albanese M.A., Hume H., Schloz L., Blazina J., Werner A., Barrasso C., Blanchette V., Warkentin P.I., Pepkowitz S., Mauer A.M., Hines D., National survey of neonatal transfusion practices: II. Blood component therapy, Pediatrics, 91, pp. 530-536, (1993)
  • [3] Levy G.J., Strauss R.G., Hume H., Schloz L., Albanese M.A., Blazina J., Werner A., Sotelo-Avila C., Barrasso C., Blanchette V., Warkentin P.I., Pepkowitz S., Mauer A.M., Hines D., National survey of neonatal transfusion practices: I. Red blood cell therapy, Pediatrics, 91, pp. 523-529, (1993)
  • [4] Stainsby D., Jones H., Wells A.W., Gibson B., Cohen H., Adverse outcomes of blood transfusion in children: analysis of UK reports to the serious hazards of transfusion scheme 1996-2005, Br J Haematol, 141, pp. 73-79, (2008)
  • [5] Bolton-Maggs P.H.B., The 2011 Annual SHOT Report
  • [6] Rashid N., Al-Sufayan F., Seshia M.M., Baier R.J., Post transfusion lung injury in the neonatal population, J Perinatol, 33, pp. 292-296, (2013)
  • [7] Gauvin F., Robillard P., Hume H., Grenier D., Whyte R.K., Webert K.E., Fergusson D., Lau W., Froese N., Delage G., Transfusion-related acute lung injury in the Canadian paediatric population, Paediatr Child Health, 17, pp. 235-239, (2012)
  • [8] Lieberman L., Petraszko T., Yi Q.L., Hannach B., Skeate R., Transfusion-related lung injury in children: a case series and review of the literature, Transfusion, 54, pp. 57-64, (2014)
  • [9] Venkatesh V., Khan R., Curley A., Hopewell S., Doree C., Stanworth S., The safety and efficacy of red cell transfusions in neonates: a systematic review of randomized controlled trials, Br J Haematol, 158, pp. 370-385, (2012)
  • [10] Mohamed A., Shah P.S., Transfusion associated necrotizing enterocolitis: a meta-analysis of observational data, Pediatrics, 129, pp. 529-540, (2012)
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