Platinum(II) complexes of reduced amino acid ester Schiff bases: synthesis, characterization, and antitumor activity

被引：0
作者：
Li-Jun Li
Cheng Wang
Yu Qiao
Xiao-Yan Yang
Xing-Xing Hua
Jian-Long Du
机构：
[1] Hebei University,Chemical Biology Key Laboratory of Hebei Province
来源：
Research on Chemical Intermediates | 2014年 / 40卷
关键词：
Platinum(II) complexes; Reduced amino acid esters Schiff-bases; DNA interaction; Antitumor activity;
D O I：
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学科分类号：
摘要：
A series of platinum(II) complexes of reduced amino acid esters Schiff bases were synthesized as potential anticancer agents and characterized by 1H NMR, EA, IR, and molar conductivity. These compounds were tested for their DNA interaction with salmon sperm DNA by ultraviolet spectrum and CD spectrum, and their in vitro anticancer activities have been validated against HL-60, KB, BGC-823, and Bel-7402 cell lines by MTT assay. The cytotoxicity of complexes 5d and 5f are better than cisplatin against Bel-7402 cell lines, and show a close cytotoxic effect against HL-60 cell line.
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页码：413 / 424
页数：11
相关论文
共 115 条
  • [1] Shaharyar M(2010)undefined Eur. J. Med. Chem. 45 114-undefined
  • [2] Abdullah MM(2011)undefined Eur. J. Med. Chem. 46 4071-undefined
  • [3] Bakht MA(1999)undefined Chem. Rev. 99 2451-undefined
  • [4] Majeed J(1999)undefined Chem. Rev. 99 2467-undefined
  • [5] Khan H(1997)undefined Coord. Chem. Rev. 166 181-undefined
  • [6] Badshah A(2001)undefined J. Med. Chem. 44 2065-undefined
  • [7] Murtaz G(2003)undefined Bioorg. Med. Chem. 11 1753-undefined
  • [8] Said M(2012)undefined New J. Chem. 36 759-undefined
  • [9] Neuhausen ZR(2003)undefined Med. Res. Rev. 23 633-undefined
  • [10] Todorova M(2006)undefined J. Am. Chem. Soc. 128 710-undefined
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