The relationship between blood pressure and serum parathyroid hormone with special reference to urinary calcium excretion: The Tromsø study

被引：0

作者：

Saleh F. ^{[1
]}

Jorde R. ^{[2
]}

Svartberg J. ^{[1
]}

Sundsfjord J. ^{[3
]}

机构：

[1] Department of Internal Medicine, University Hospital of North Norway

[2] Institute of Clinical Medicine, University of Tromsø, Tromsø

[3] Department of Clinical Chemistry, University Hospital of North Norway

来源：

Journal of Endocrinological Investigation | 2006年 / 29卷 / 3期

关键词：

Blood pressure; Parathyroid hormone; Urinary calcium excretion; Urinary sodium excretion;

D O I：

10.1007/BF03345542

中图分类号：

学科分类号：

摘要：

The aim of the present cross-sectional epidemiological study from Tromso, Northern Norway, was to evaluate the relation between blood pressure and serum PTH, and to examine whether this relation can be explained by a blood pressure-induced increase in urinary calcium. Ten thousand-four hundred and nineteen subjects were invited to participate and 8128 attended. Those with serum calcium outside the reference range (2.20-2.60 mmol/l), with increased serum creatinine (upper limit 120 μmol/l for men and 100 μmol/l for women) and those using antihypertensive medication were excluded. Three thousand-six hundred and twenty subjects had complete data on outcome measures. Height, weight, blood pressure, serum calcium, PTH, and creatinine were measured and smoking status recorded. A morning urine sample was collected and urinary calcium, sodium and creatinine measured. The urinary calcium/urinary creatinine ratio (Uca/Ucr) and urinary sodium/urinary creatinine ratio (Una/Ucr) were calculated. There was a significant association between both systolic and diastolic blood pressure and serum PTH. The Uca/Ucr increased with increasing blood pressure. However, the Uca/Ucr did not affect the association between blood pressure and serum PTH in a multiple linear regression model. The relationship between blood pressure and serum PTH was also seen in subjects with similar Uca/Ucr, and a negative association between serum PTH and the Uca/Ucr was found. In conclusion, blood pressure and serum PTH are associated. This association cannot be explained by the urinary calcium excretion alone. © 2006, Editrice Kurtis.

引用

页码：214 / 220

页数：6

共 26 条

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