RCAN1 deficiency aggravates sepsis-induced cardiac remodeling and dysfunction by accelerating mitochondrial pathological fission

[1] Singer M(2016)The third international consensus definitions for sepsis and septic shock (Sepsis-3) JAMA 315 801-810

[2] Deutschman CS(2021)Emerging mechanisms of immunocoagulation in sepsis and septic shock Trends Immunol 42 508-522

[3] Seymour CW(2020)TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis Nat Immunol 21 1585-1596

[4] Shankar-Hari M(2020)Sepsis-induced myocardial dysfunction (SIMD): the pathophysiological mechanisms and therapeutic strategies targeting mitochondria Inflammation 43 1184-1200

[5] Annane D(2021)Cooperative binding of ETS2 and NFAT Links Erk1/2 and calcineurin signaling in the pathogenesis of cardiac hypertrophy Circulation 144 34-51

[6] Bauer M(2021)Piezo1-mediated mechanotransduction promotes cardiac hypertrophy by impairing calcium homeostasis to activate calpain/calcineurin signaling Hypertension (Dallas, Tex, 1979) 78 647-660

[7] Tang D(2007)Lipopolysaccharide activates calcineurin in ventricular myocytes J Am Coll Cardiol 49 491-499

[8] Wang H(2008)Lipopolysaccharide induces cellular hypertrophy through calcineurin/NFAT-3 signaling pathway in H9c2 myocardiac cells Mol Cell Biochem 313 167-178

[9] Billiar TR(2009)Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point Nat Cell Biol 11 154-161

[10] Kroemer G(2014)Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion J Mol Cell Cardiol 74 103-111

[1] Singer M(2016)The third international consensus definitions for sepsis and septic shock (Sepsis-3) JAMA 315 801-810

[2] Deutschman CS(2021)Emerging mechanisms of immunocoagulation in sepsis and septic shock Trends Immunol 42 508-522

[3] Seymour CW(2020)TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis Nat Immunol 21 1585-1596

[4] Shankar-Hari M(2020)Sepsis-induced myocardial dysfunction (SIMD): the pathophysiological mechanisms and therapeutic strategies targeting mitochondria Inflammation 43 1184-1200

[5] Annane D(2021)Cooperative binding of ETS2 and NFAT Links Erk1/2 and calcineurin signaling in the pathogenesis of cardiac hypertrophy Circulation 144 34-51

[6] Bauer M(2021)Piezo1-mediated mechanotransduction promotes cardiac hypertrophy by impairing calcium homeostasis to activate calpain/calcineurin signaling Hypertension (Dallas, Tex, 1979) 78 647-660

[7] Tang D(2007)Lipopolysaccharide activates calcineurin in ventricular myocytes J Am Coll Cardiol 49 491-499

[8] Wang H(2008)Lipopolysaccharide induces cellular hypertrophy through calcineurin/NFAT-3 signaling pathway in H9c2 myocardiac cells Mol Cell Biochem 313 167-178

[9] Billiar TR(2009)Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point Nat Cell Biol 11 154-161

[10] Kroemer G(2014)Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion J Mol Cell Cardiol 74 103-111