Pyridoxal 5"-Phosphate as a Catalytic and Conformational Cofactor of Muscle Glycogen Phosphorylase b

被引：0

作者：

N. B. Livanova

N. A. Chebotareva

T. B. Eronina

B. I. Kurganov

机构：

[1] Russian Academy of Sciences,Bach Institute of Biochemistry

来源：

Biochemistry (Moscow) | 2002年 / 67卷

关键词：

glycogen phosphorylase ; mechanism of reaction; pyridoxal 5"-phosphate; regulation; thermal inactivation; quaternary structure;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This review summarizes data on structure of muscle glycogen phosphorylase b and the role of the cofactor pyridoxal 5"-phosphate in catalysis and stabilizing the native conformation of the enzyme. Specific attention is paid to the stabilizing role of pyridoxal 5"-phosphate upon denaturation of phosphorylase b. Stability of holoenzyme, apoenzyme, and enzyme reduced by sodium borohydride is compared.

引用

页码：1089 / 1098

页数：9

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