Thiopurines in inflammatory bowel disease: New strategies for optimization of pharmacotherapy?

被引：7
作者：
Luc J. J. Derijks
Daniel W. Hommes
机构：
[1] Máxima Medical Center,Department of Clinical Pharmacy
来源：
Current Gastroenterology Reports | 2006年 / 8卷 / 2期
关键词：
Therapeutic Drug Monitoring; Thiopurine; Nodular Regenerative Hyperplasia; Thiopurine Therapy; TPMT Genotyping;
D O I：
10.1007/s11894-006-0001-0
中图分类号：
学科分类号：
摘要：
New strategies for optimizing thiopurine therapy of IBD are promising. TDM and TPMT genotyping seem to be important tools for fine tuning thiopurine therapy, thereby reducing toxicity and improving efficacy. ITPA genotyping and the use of 6-TG in IBD need further research before they can be advocated or banned.
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页码：89 / 92
页数：3
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