Thiopurines in inflammatory bowel disease: New strategies for optimization of pharmacotherapy?

被引：7
作者：
Luc J. J. Derijks
Daniel W. Hommes
机构：
[1] Máxima Medical Center,Department of Clinical Pharmacy
来源：
Current Gastroenterology Reports | 2006年 / 8卷 / 2期
关键词：
Therapeutic Drug Monitoring; Thiopurine; Nodular Regenerative Hyperplasia; Thiopurine Therapy; TPMT Genotyping;
D O I：
10.1007/s11894-006-0001-0
中图分类号：
学科分类号：
摘要：
New strategies for optimizing thiopurine therapy of IBD are promising. TDM and TPMT genotyping seem to be important tools for fine tuning thiopurine therapy, thereby reducing toxicity and improving efficacy. ITPA genotyping and the use of 6-TG in IBD need further research before they can be advocated or banned.
引用
收藏
页码：89 / 92
页数：3
相关论文
共 119 条
[1]  
Adler DJ(1990)The therapeutic efficacy of 6-mercaptopurine in refractory ulcerative colitis Am J Gastroenterol 85 717-722
[2]  
Korelitz BI(1995)Azathioprine and 6-mercaptopurine in Crohn disease: a meta-analysis Ann Intern Med 123 132-142
[3]  
Pearson DC(1996)A review of immune modifier therapy for inflammatory bowel disease: azathioprine, 6-mercaptopurine, cyclosporine, and methotrexate Am J Gastroenterol 91 423-433
[4]  
May GR(1998)Safety of azathioprine and 6-mercaptopurine in pediatric patients with inflammatory bowel disease Gastroenterology 115 813-821
[5]  
Fick GH(1989)6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity Ann Intern Med 111 641-649
[6]  
Sandborn WJ(1993)Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience Gut 34 1081-1085
[7]  
Kirschner BS(1992)High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample J Chromatogr 583 83-90
[8]  
Present DH(1998)Simultaneous determination of 6-thioguanine and methyl 6-mercaptopurine nucleotides of azathioprine in red blood cells by HPLC Clin Chem 44 551-555
[9]  
Meltzer SJ(1990)A reversed phase high performance liquid chromatography approach in determining total red blood cell concentrations of 6-thioguanine, 6-mercaptopurine, methylthioguanine, and methylmercaptopurine in a patient receiving thiopurine therapy Biomed Chromatogr 4 47-51
[10]  
Krumholz MP(1996)6-Mercaptopurine metabolism in Crohn’s disease: correlation with efficacy and toxicity Gut 39 401-406
12345678910