Pamidronate treatment in acute vitamin D intoxication

被引：0
作者：
F. Gurkan
M. Davutoglu
M. Bosnak
A. Ece
B. Dikici
M. Bilici
K. Haspolat
机构：
[1] Dicle University Medical School,Department of Pediatrics, Pediatric Emergency Unit
[2] Dicle University Medical School,Department of Pediatrics
[3] Dicle University Medical School,Department of Pediatrics, Pediatric Emergency and Pediatric Intensive Care Units
来源：
Journal of Endocrinological Investigation | 2004年 / 27卷
关键词：
Acute; pamidronate; vitamin D intoxication;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Management with glucocorticoid, high iv fluid saline intake, furosemide and calcitonin may not result in a favorable reduction of hypercalcemia and may cause several side effects in infants with acute vitamin D intoxication. The bisphosphonate pamidronate, a specific inhibitor of bone resorption through osteoclast mediation was successfully used in a 6-month old infant with acute vitamin D intoxication managed in the Pediatric Emergency and Intensive Care Unit, after an ineffective trial of hydration, furosemide, calcitonin and prednisolone. After a double infusion of pamidronate on two consecutive days (1 mg/kg/day), an early and safe correction of hypercalcemia/hypercalciuria was supplied. Pamidronate therapy may be considered in patients with hypercalcemia secondary to acute vitamin D poisoning.
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页码：680 / 682
页数：2
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