Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases

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作者：
Dorothea M. Heuberger
Reto A. Schuepbach
机构：
[1] Institute of Intensive Care Medicine,Surgical Research Division
[2] University Hospital Zurich,undefined
[3] University of Zurich,undefined
[4] University Hospital Zurich,undefined
[5] University of Zurich,undefined
来源：
Thrombosis Journal | / 17卷
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摘要：
Inflammatory diseases have become increasingly prevalent with industrialization. To address this, numerous anti-inflammatory agents and molecular targets have been considered in clinical trials. Among molecular targets, protease-activated receptors (PARs) are abundantly recognized for their roles in the development of chronic inflammatory diseases. In particular, several inflammatory effects are directly mediated by the sensing of proteolytic activity by PARs.
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