Thrombotic complications without evidence of hemolysis in paroxysmal nocturnal hemoglobinuria: is eculizumab indicated?

被引:0
作者
M. Bellido
V. H. J. van der Velden
F. W. G. Leebeek
P. A. W. te Boekhorst
机构
[1] Erasmus Medical Center,Department of Hematology
[2] Erasmus Medical Center,Department of Immunology
来源
Annals of Hematology | 2012年 / 91卷
关键词
Anticoagulant Therapy; Paroxysmal Nocturnal Hemoglobinuria; Eculizumab; Thrombotic Complication; Nadroparin;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1969 / 1970
页数:1
相关论文
共 32 条
[1]  
van Bijnen STA(2012)Mechanism and clinical implications of thrombosis in paroxysmal nocuternal hemoglobinuria J Thrombo Haemost 10 1-10
[2]  
van Heerde WL(2007)Effect of the complement inhibitor eculizumab on thromboembolism in patient with paroxysmal nocturnal hemoglobinuria Blood 110 4123-4128
[3]  
Muus P(2005)The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease JAMA 293 1653-1662
[4]  
Hillmen P(2011)Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival Blood 117 6786-6792
[5]  
Muus P(2011)Management of paroxysmal nocturnal haemoglobinuria: a personal view Br J Haematol 153 709-720
[6]  
Dührsen U(1993)Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria Blood 82 1192-1196
[7]  
Rother RP(2004)Rapid regulation of platelet activation in vivo by nitric oxide Circulation 109 1819-1822
[8]  
Bell L(1989)Regulatory control of complement on blood platelets. Modulation of platelet procoagulant responses by a membrane inhibitor of the C5b-9 complex J Biol Chem 264 19228-19235
[9]  
Hillmen P(2009)treat paroxysmal nocturnal hemoglobinuria Blood 113 6522-6527
[10]  
Kelly RJ(2000)Paroxysmal nocturnal hemoglobinuria with no evidence of hemolysis presenting as Budd-Chiari syndrome Dig Dis Sci 45 2238-2239