HIV takes double hit before entry

被引：0
作者：
Rogier W Sanders
机构：
[1] University of Amsterdam,Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center
[2] Weill Medical College of Cornell University,Department of Microbiology and Immunology
来源：
BMC Biology | / 10卷
关键词：
Fusion Peptide; Maraviroc; Viral Life Cycle; Enfuvirtide; Free Virus;
D O I：
暂无
中图分类号：
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摘要：
In the absence of a vaccine or a cure, identification of novel HIV-1 inhibitors remains important. A paper in Retrovirology describes a rationally designed bi-specific protein that irreversibly damages the viral envelope glycoprotein complex via a two-punch mechanism. In contrast to traditional drugs that inhibit essential steps in the viral life cycle at the cell surface or in the infected cells, this inhibitor cripples free virus in the absence of cells.
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