RETRACTED ARTICLE: Jawbone microenvironment promotes periodontium regeneration by regulating the function of periodontal ligament stem cells

被引：0
作者：
Bin Zhu
Wenjia Liu
Yihan Liu
Xicong Zhao
Hao Zhang
Zhuojing Luo
Yan Jin
机构：
[1] State Key Laboratory of Military Stomatology,Department of Orthopedics Surgery
[2] Centre for Tissue Engineering,Department of Stomatology
[3] School of Stomatology,undefined
[4] Fourth Military Medical University,undefined
[5] Xijing Hospital,undefined
[6] Fourth Military Medical University,undefined
[7] PLA Xizang Military Region General Hospital,undefined
[8] Department of Stomatology,undefined
来源：
Scientific Reports | / 7卷
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摘要：
During tooth development, the jawbone interacts with dental germ and provides the development microenvironment. Jawbone-derived mesenchymal stem cells (JBMSCs) maintain this microenvironment for root and periodontium development. However, the effect of the jawbone microenvironment on periodontium tissue regeneration is largely elusive. Our previous study showed that cell aggregates (CAs) of bone marrow mesenchymal stem cells promoted periodontium regeneration on the treated dentin scaffold. Here, we found that JBMSCs enhanced not only the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) but also their adhesion to titanium (Ti) material surface. Importantly, the compound CAs of PDLSCs and JBMSCs regenerated periodontal ligament-like fibers and mineralized matrix on the Ti scaffold surface, both in nude mice ectopic and minipig orthotopic transplantations. Our data revealed that an effective regenerative microenvironment, reconstructed by JBMSCs, promoted periodontium regeneration by regulating PDLSCs function on the Ti material.
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  • [1] Slavkin HC(1991)Molecular determinants during dental morphogenesis and cytodifferentiation: a review J Craniofac Genet Dev Biol 11 338-349
  • [2] Luan X(2006)Evolution and development of Hertwig’s epithelial root sheath Dev Dyn 235 1167-1180
  • [3] Ito Y(1995)Epithelial-mesenchymal signaling during tooth development Connect Tissue Res 32 9-15
  • [4] Diekwisch TG(2003)Tooth and jaw: molecular mechanisms of patterning in the first branchial arch Arch Oral Biol 48 1-14
  • [5] Thesleff I(1993)Tissue engineering Science 260 920-926
  • [6] Vaahtokari A(2005)Alveolar bone marrow as a cell source for regenerative medicine: differences between alveolar and iliac bone marrow stromal cells J Bone Miner Res 20 399-409
  • [7] Kettunen P(2007)Human maxillary tuberosity and jaw periosteum as sources of osteoprogenitor cells for tissue engineering Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104 618 e611-612
  • [8] Aberg T(2014)Standardization and safety of alveolar bone-derived stem cell isolation J Dent Res 93 55-61
  • [9] Cobourne MT(2011)The mechanical function of the periodontal ligament in the macaque mandible: a validation and sensitivity study using finite element analysis J Anat 218 75-86
  • [10] Sharpe PT(2004)Investigation of multipotent postnatal stem cells from human periodontal ligament Lancet 364 149-155
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