Sustained-release diclofenac potassium orally disintegrating tablet incorporating eudragit ERL/ERS: Possibility of specific diclofenac-polymer interaction

被引：10

作者：

Qandil A.M. ^{[1
,2
]}

Assaf S.M. ^{[3
]}

Al Ani E.A. ^{[3
]}

Yassin A.E. ^{[2
]}

Obaidat A.A. ^{[3
,4
]}

机构：

[1] Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid

[2] Pharmaceutical Sciences Department, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh

[3] Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid

[4] Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh

来源：

Journal of Pharmaceutical Investigation | 2013年 / 43卷 / 3期

关键词：

Diclofenac; Eudragit RL; Eudragit RS; Orally disintegrating tablet; Sustained-release;

D O I：

10.1007/s40005-013-0065-4

中图分类号：

学科分类号：

摘要：

Sustained-release diclofenac potassium orally disintegrating tablet (ODT) formulations have been prepared and investigated. The ODTs were prepared by incorporating diclofenac potassium (DP), as a model for negatively ionizable drugs, in microcapsules that were prepared by the solvent evaporation method from a mixture of DP and different ratios of Eudragit RS and Eudragit RL, which are positively ionized synthetic polymers. The ODTs were prepared by direct compression of mixtures containing microcapsule formula M4, crospovidone as a superdisintegrant and water soluble excipients (mannitol or lactose and sorbitol). Diclofenac potassium ODT F2, showed acceptable hardness (4.08 KP) slight friability (2.13 %) and disintegration time of 22.41 s with a sustained drug release profile. Microcapsule characterization (DSC and FT-IR) and dissolution behavior suggests the presence of specific interaction between the carboxylate group of diclofenac and the quaternary ammonium group in the polymers © 2013 The Korean Society of Pharmaceutical Sciences and Technology.

引用

页码：171 / 183

页数：12

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