Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

被引：0

作者：

Mingfeng Liao

Yang Liu

Jing Yuan

Yanling Wen

Gang Xu

Juanjuan Zhao

Lin Cheng

Jinxiu Li

Xin Wang

Fuxiang Wang

Lei Liu

Ido Amit

Shuye Zhang

Zheng Zhang

机构：

[1] Institute for Hepatology,Department for Infectious Diseases

[2] National Clinical Research Center for Infectious Disease,Department of Immunology

[3] Shenzhen Third People’s Hospital,undefined

[4] Shenzhen Third People’s Hospital,undefined

[5] The Second Affiliated Hospital,undefined

[6] School of Medicine,undefined

[7] Southern University of Science and Technology,undefined

[8] Weizmann Institute of Science,undefined

[9] Shanghai Public Health Clinical Center,undefined

[10] Fudan University,undefined

来源：

Nature Medicine | 2020年 / 26卷

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摘要：

Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.

引用

页码：842 / 844

页数：2