Allosteric inhibition of antiapoptotic MCL-1

被引：0
|
作者：
Susan Lee
Thomas E Wales
Silvia Escudero
Daniel T Cohen
James Luccarelli
Catherine G Gallagher
Nicole A Cohen
Annissa J Huhn
Gregory H Bird
John R Engen
Loren D Walensky
机构：
[1] Dana-Farber Cancer Institute,Department of Pediatric Oncology
[2] Linde Program in Cancer Chemical Biology,Department of Chemistry and Chemical Biology
[3] Dana-Farber Cancer Institute,Division of Hematology/Oncology
[4] Northeastern University,undefined
[5] Boston Children's Hospital,undefined
来源：
Nature Structural & Molecular Biology | 2016年 / 23卷
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摘要：
Identification of an allosteric mechanism disrupting the antiapoptotic BH3 binding activity of MCL-1 offers a new approach for targeting the apoptotic resistance of human cancers.
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页码：600 / 607
页数：7
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