The effect of quercetin on hepatic differentiation of human adipose-derived mesenchymal stem cells

被引：3

作者：

Pinchuk S.V. ^{[1
]}

Vasilevich I.B. ^{[1
]}

Kvacheva Z.B. ^{[1
]}

Volotovski I.D. ^{[1
]}

机构：

[1] Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus, Minsk

来源：

Cell and Tissue Biology | 2016年 / 10卷 / 5期

关键词：

hepatic differentiation; mesenchymal stem cells; quercetin;

D O I：

10.1134/S1990519X16050102

中图分类号：

学科分类号：

摘要：

Human adipose-derived mesenchymal stem cells (MSCs) can be stimulated to differentiate into hepatic cells. MSC differentiation was induced by fibroblast growth factor-4, hepatocyte growth factor, oncostatin M, and dexamethasone. The influence of quercetin on MSC hepatic differentiation in culture was assayed, and 1 or 10 μmole/L quercetin added into the induction medium enhanced the manifestation of MSC hepatic differentiation. Urea secretion, cytokeratin 19 expression, and α-fetoprotein synthesis were increased. Quercetin modulated CYP1A–cytochrome P450 activity in the differentiated cells. MSCs differentiated in the presence of quercetin exhibited higher viability and resistance to oxidative stress. © 2016, Pleiades Publishing, Ltd.

引用

页码：357 / 364

页数：7

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