The effect of quercetin on hepatic differentiation of human adipose-derived mesenchymal stem cells

被引：3
|
作者：
Pinchuk S.V. [1 ]
Vasilevich I.B. [1 ]
Kvacheva Z.B. [1 ]
Volotovski I.D. [1 ]
机构：
[1] Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus, Minsk
来源：
Cell and Tissue Biology | 2016年 / 10卷 / 5期
关键词：
hepatic differentiation; mesenchymal stem cells; quercetin;
D O I：
10.1134/S1990519X16050102
中图分类号：
学科分类号：
摘要：
Human adipose-derived mesenchymal stem cells (MSCs) can be stimulated to differentiate into hepatic cells. MSC differentiation was induced by fibroblast growth factor-4, hepatocyte growth factor, oncostatin M, and dexamethasone. The influence of quercetin on MSC hepatic differentiation in culture was assayed, and 1 or 10 μmole/L quercetin added into the induction medium enhanced the manifestation of MSC hepatic differentiation. Urea secretion, cytokeratin 19 expression, and α-fetoprotein synthesis were increased. Quercetin modulated CYP1A–cytochrome P450 activity in the differentiated cells. MSCs differentiated in the presence of quercetin exhibited higher viability and resistance to oxidative stress. © 2016, Pleiades Publishing, Ltd.
引用
收藏
页码：357 / 364
页数：7
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