STIM1 senses both Ca2+ and heat

被引：0

作者：

Salvatore Mancarella

Youjun Wang

Donald L Gill

机构：

[1] Salvatore Mancarella,Youjun Wang and Donald L. Gill are in the Department of Biochemistry

[2] Temple University School of Medicine,undefined

[3] Philadelphia,undefined

[4] Pennsylvania,undefined

[5] USA.,undefined

来源：

Nature Chemical Biology | 2011年 / 7卷

关键词：

D O I：

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学科分类号：

摘要：

STIM proteins are ubiquitous endoplasmic reticulum Ca2+ sensors that rapidly translocate to couple with 'store-operated' Orai Ca2+ channels when luminal Ca2+ levels are low. STIM1 also senses heat changes, which trigger a similar translocation and prime STIM1 to activate Orai, suggesting that STIM1 functions as a sensor of multiple stress signals.

引用

页码：344 / 345

页数：1

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