STIM1 senses both Ca2+ and heat

被引：0
|
作者：
Salvatore Mancarella
Youjun Wang
Donald L Gill
机构：
[1] Salvatore Mancarella,Youjun Wang and Donald L. Gill are in the Department of Biochemistry
[2] Temple University School of Medicine,undefined
[3] Philadelphia,undefined
[4] Pennsylvania,undefined
[5] USA.,undefined
来源：
Nature Chemical Biology | 2011年 / 7卷
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摘要：
STIM proteins are ubiquitous endoplasmic reticulum Ca2+ sensors that rapidly translocate to couple with 'store-operated' Orai Ca2+ channels when luminal Ca2+ levels are low. STIM1 also senses heat changes, which trigger a similar translocation and prime STIM1 to activate Orai, suggesting that STIM1 functions as a sensor of multiple stress signals.
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页码：344 / 345
页数：1
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