No Association Between Base Excision Repair Gene Polymorphisms and Risk of Lung Cancer

被引：0
作者：
Ulla Vogel
Bjørn A. Nexø
Håkan Wallin
Kim Overvad
Anne Tjønneland
Ole Raaschou-Nielsen
机构：
[1] National Institute of Occupational Health,Institute of Human Genetics
[2] University of Aarhus,Department of Clinical Epidemiology
[3] Aalborg Hospital and Aarhus University Hospital,undefined
来源：
Biochemical Genetics | 2004年 / 42卷
关键词：
OGG1; XRCC1; base excision; polymorphisms; lung cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In a nested case–cohort study, we have investigated the occurrence of lung cancer in relation to polymorphisms in base excision repair genes XRCC1 and OGG1. Among 54,220 members of a Danish prospective cohort study, aged 50–65 years at entry, 265 lung cancer cases were identified and a subcohort comprising 272 individuals was used for comparison. No associations were found between the polymorphisms OGG1 Ser326Cys, XRCC1Arg280His, and XRCC1 Arg399Gln and risk of lung cancer. This is the first study of polymorphisms in base excision repair genes in relation to lung cancer among Danes.
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页码：453 / 460
页数：7
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