Expression of Thrombospondin-1 Gene mRNA and Protein in the Placenta in Gestosis

被引：0
作者：
Yu. V. Ostankova
Ya. S. Klimovskaya
O. A. Gorskaya
A. V. Kolobov
I. M. Kvetnoi
S. A. Selkov
D. I. Sokolov
机构：
[1] North Western Division of the Russian Academy of Medical Sciences,D. O. Ott Institute of Obstetrics and Gynecology
来源：
Bulletin of Experimental Biology and Medicine | 2011年 / 151卷
关键词：
thrombospondin; placenta; gestosis; macrophages; angiogenesis;
D O I：
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中图分类号：
学科分类号：
摘要：
The expression of TSP-1 gene mRNA and TSP-1 protein in the placental tissue was studied during normal pregnancy and in gestosis. The formation of placental tissue in normal gestation was associated with expression of TSP-1 gene mRNA and of TSP-1 protein. Gestosis was associated with infl ammatory reaction in the placenta characterized by increased counts of lymphocytes and macrophages in the villous stroma and involution degenerative changes in tissue. Disorders in placental villi maturation and branching in gestosis were paralleled by hyperexpression of TSP-1 gene mRNA by placental cells and hyperexpression of TSP-1 protein predominating in the stromal elements of terminal villi and near villous vessels.
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页码：215 / 218
页数：3
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