Fumonisin B1 Metabolism by Bovine Liver Microsomes

被引：0
作者：
M. Spotti
G. Pompa
F. Caloni
机构：
[1] University of Milan,Department of Veterinary Sciences and Technology for Food Safety
[2] Faculty of Veterinary Medicine,undefined
来源：
Veterinary Research Communications | 2001年 / 25卷
关键词：
bovine; fumonisin B; liver; metabolism; microsome; tolerance;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Only limited and contrasting information is available about the metabolic fate in cattle of fumonisin B1, a mycotoxin produced by moulds of Fusarium. This study was carried out to evaluate the hepatic metabolism of fumonisin B1 by bovine liver microsomes. No biodegradation or metabolization of the mycotoxin by liver microsomes was detectable after incubating fumonisin B1 with bovine microsomes in the presence of a regenerating system for 1 h. No aminopolyol 1, aminopolyol 2 or aminopentol, metabolites of fumonisin B1, were detected in any of the incubated samples. The tolerance of ruminants to fumonisin B1 is apparently not dependent on its detoxification in the rumen.
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页码：511 / 516
页数：5
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