Engineering and expression of a recombinant fusion protein possessing fibroblast growth factor-2 and fibronectin fragment

被引：0
|
作者：
Jun-Hyeog Jang
Chong-Pyoung Chung
机构：
[1] Inha University College of Medicine,Department of Biochemistry
[2] Seoul National University College of Dentistry,Intellectual Biointerface Engineering Center and Department of Periodontology
来源：
Biotechnology Letters | 2004年 / 26卷
关键词：
cell adhesion; extracellular matrix; fibroblast growth factor; fibronectin; fusion;
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学科分类号：
摘要：
There is a synergistic effect between fibronectin and fibroblast growth factor 2 (FGF-2) on osteoblast cell adhesion through an extracellular, signal-regulated kinase pathway. Here we describe the engineering of a fusion protein containing fibronectin fragment (FNIII9-10) connected to the COOH-terminus of FGF-2. Purified FGF2-FNIII9-10 fusion protein exhibited a significant increase of cell adhesion and proliferation of MG63 cells compared with FNIII9-10 alone (p < 0.05).
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页码：1837 / 1840
页数：3
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