Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2

被引：0

作者：

Margarita Malakhova

Valentina Tereshko

Sung-Young Lee

Ke Yao

Yong-Yeon Cho

Ann Bode

Zigang Dong

机构：

[1] The Hormel Institute,Department of Biochemistry and Molecular Biology

[2] University of Minnesota,undefined

[3] University of Chicago,undefined

[4] Gordon Center for Integrative Science,undefined

[5] Room W216,undefined

[6] 929 East 57th Street,undefined

[7] University of Chicago,undefined

来源：

Nature Structural & Molecular Biology | 2008年 / 15卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The X-ray structure at 2.0-Å resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory αL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the αL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.

引用

页码：112 / 113

页数：1

共 50 条

[1] Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2
Malakhova, Margarita
Tereshko, Valentina
Lee, Sung-Young
Yao, Ke
Cho, Yong-Yeon
Bode, Ann
Dong, Zigang
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (01) : 112 - 113
[2] Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases
Fruergaard, Marlene Uglebjerg
Nielsen, Christine Juul Faelled
Kjeldsen, Cecilia Rosada
Iversen, Lars
Andersen, Jacob Lauwring
Nissen, Poul
LIFE SCIENCE ALLIANCE, 2023, 6 (05)
[3] Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1
Li, Dan
Fu, Tian-Min
Nan, Jie
Liu, Cong
Li, Lan-Fen
Su, Xiao-Dong
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 2012, 68 : 680 - 685
[4] Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution
Derewenda, Urszula
Artamonov, Mykhaylo
Szukalska, Gabriela
Utepbergenov, Darkhan
Olekhnovich, Natalya
Parikh, Hardik I.
Kellogg, Glen E.
Somlyo, Avril V.
Derewenda, Zygmunt S.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2013, 69 : 266 - 275
[5] Cloning and characterization of Xenopus Rsk2, the predominant p90 Rsk isozyme in oocytes and eggs
Bhatt, RR
Ferrell, JE
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (42) : 32983 - 32990
[6] Fibroblast Growth Factor Receptor 3 Associates with and Tyrosine Phosphorylates p90 RSK2, Leading to RSK2 Activation That Mediates Hematopoietic Transformation
Kang, Sumin
Elf, Shannon
Dong, Shaozhong
Hitosugi, Taro
Lythgoe, Katherine
Guo, Ailan
Ruan, Hong
Lonial, Sagar
Khoury, Hanna J.
Williams, Ifor R.
Lee, Benjamin H.
Roesel, Johannes L.
Karsenty, Gerard
Hanauer, Andre
Taunton, Jack
Boggon, Titus J.
Gu, Ting-Lei
Chen, Jing
MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (08) : 2105 - 2117
[7] Insights into the Inhibition of the p90 Ribosomal 56 Kinase (RSK) by the Flavonol Glycoside SL0101 from the 1.5 Å Crystal Structure of the N-Terminal Domain of RSK2 with Bound Inhibitor
Utepbergenov, Darkhan
Derewenda, Urszula
Olekhnovich, Natalya
Szukalska, Gabriela
Banerjee, Budhaditya
Hilinski, Michael K.
Lannigan, Deborah A.
Stukenberg, P. Todd
Derewenda, Zygmunt S.
BIOCHEMISTRY, 2012, 51 (33) : 6499 - 6510
[8] Conformations of p90 Ribosomal S6 Kinase (RSK) Activation
Kobori, Evan
Chen, Katherine
Taylor, Susan
FASEB JOURNAL, 2022, 36
[9] PHOSPHORYLATION AND ACTIVATION OF P90(RSK) BY GLYCOGEN-SYNTHASE KINASE-3
WANG, QM
VIK, TA
RYDER, JW
ROACH, PJ
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 208 (02) : 796 - 801
[10] Structural Studies and Dynamics of p90 Ribosomal S6 Kinase (RSK)
Kobori, Evan
Taylor, Susan
FASEB JOURNAL, 2021, 35

← 1 2 3 4 5 →