Demyelinating disease and anti-N-methyl-Daspartate receptor immunoglobulin G antibodies: A case report

被引：12

作者：

Waschbisch A. ^{[1
]}

Kallmünzer B. ^{[1
]}

Schwab S. ^{[1
]}

Gölitz P. ^{[2
]}

Vincent A. ^{[3
]}

Lee D.-H. ^{[1
]}

Linker R.A. ^{[1
]}

机构：

[1] Department of Neurology, Friedrich-Alexander University of Erlangen, Schwabachanlage 6, Erlangen

[2] Department of Neuroradiology, Friedrich-Alexander University of Erlangen, Schwabachanlage 6, Erlangen

[3] Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford

来源：

BMC Research Notes | / 7卷 / 1期

关键词：

Anti-neuronal antibodies; Demyelinating disease; Encephalitis; Multiple Sclerosis; Neuroinflammation; NMDA receptor antibody;

D O I：

10.1186/1756-0500-7-948

中图分类号：

学科分类号：

摘要：

Background: Anti-N-methyl-D-aspartate receptor immunoglobulin G antibodies directed against the GluN1 subunit are considered highly specific for anti-N-methyl-D-aspartate receptor encephalitis, a severe clinical syndrome characterized by seizures, psychiatric symptoms, orofacial dyskinesia and autonomic dysfunction. Case presentation: Here we report a 33 year old Caucasian male patient with clinically definite multiple sclerosis who was found to be positive for anti-N-methyl-D-aspartate receptor antibodies. Rituximab therapy was initiated. On the 18 months follow-up visit the patient was found to be clinically stable, without typical signs of anti-N-methyl-D-aspartate receptor encephalitis. Conclusion: Our findings add to the growing evidence for a possible association between anti-N-methyl-D-aspartate receptor encephalitis and demyelinating diseases. © 2015 Waschbisch et al.; licensee BioMed Central.

引用

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