Intensifying Iodine Deficiency Throughout Trimesters of Pregnancy in a Borderline Iodine-Sufficient Urban Area, Ankara, Turkey

被引:0
作者
Aynur Köse Aktaş
Asena Gökçay Canpolat
Ünsal Aydin
Hakkı Yilmaz
Berna İmge Aydogan
Kudret Erkenekli
Gönül Koç
Yalçın Aral
Murat Faik Erdoğan
机构
[1] Ankara Training and Research Hospital,Department of Endocrinology and Metabolism
[2] Ankara University School of Medicine,Department of Endocrinology and Metabolism
[3] Nephrology Clinic,Department of Endocrinology and Metabolism
[4] Dr. Abdurrahman Yurtaslan Oncology Training,undefined
[5] and Research Hospital,undefined
[6] Zekai Tahir Burak Women’s Health Care,undefined
[7] Education,undefined
[8] and Research Hospital,undefined
[9] Yozgat Bozok University,undefined
来源
Biological Trace Element Research | 2022年 / 200卷
关键词
Iodization; Pregnancy; Hypothyroidism; Thyroid volume;
D O I
暂无
中图分类号
学科分类号
摘要
Iodine has long been recognized as an essential micronutrient for maternal thyroid function, as well as fetal growth and development during pregnancy. The current study aimed to evaluate thyroid hormone status, urinary iodine concentration (UIC), thyroid volume, and nodularity in pregnant women, throughout trimesters, in a borderline iodine sufficient, urban area with mandatory table salt iodization. Two-hundred-sixty-five pregnant women ranging from 17 to 45 years participated in this prospective longitudinal study. Thyroid function tests, thyroid volume, nodule growth, and UIC were recorded throughout the first, second, and third trimesters with no intervention. Median UIC was 96, 78, and 60 µg/L in the first, second, and third trimester of pregnancy, respectively (p < 0.001). Mean TSH values increased significantly (i.e. 0.65 mIU/ml, 1.1 mIU/ml, and 1.3 mIU/ml in the first, second, and third trimesters, respectively) (p < 0.001). Mean ± s.d. thyroid volume was significantly higher in the third trimester (14.72 ± 6.8 ml) compared with the first trimester (13.69 ± 5.31 ml) (p < 0.001). An intensifying iodine deficiency (ID) was reported throughout trimesters in this cohort of pregnant women from Ankara. A significant percentage of pregnant women from a borderline iodine sufficient, urban area in Turkey were iodine deficient during all trimesters, and the deficiency increased throughout the pregnancy. Pregnant women should receive iodine supplementation, besides consuming iodized salt in borderline iodine sufficient areas.
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页码:2667 / 2672
页数:5
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共 158 条
  • [11] Xiao Y(2018)High prevalence of iodine deficiency in pregnant women living in adequate iodine area Endocr Connect 7 762-268
  • [12] Sun H(2018)Iodine status during pregnancy in a region of mild-to-moderate iodine deficiency is not associated with adverse obstetric outcomes; results from the Avon Longitudinal Study of Parents and Children (ALSPAC) Nutrients 10 291-687
  • [13] Li C(2002)Iodine status and goiter prevalence in Turkey before mandatory iodization J Endocrinol Invest 25 224-126
  • [14] Li Y(2009)More than a decade of iodine prophylaxis is needed to eradicate goiter among school age children in a moderately iodine-deficient region Thyroid 19 265-596
  • [15] Peng S(2016)Maternal iodine insufficiency and adverse pregnancy outcomes Matern Child Nutr 12 680-477
  • [16] Fan C(2015)Reporting thyroid function tests in pregnancy Clin Biochem Rev 36 109-433
  • [17] Teng W(2013)Screening for maternal thyroid dysfunction in pregnancy: a review of the clinical evidence and current guidelines J Thyroid Res 2013 851326-1014
  • [18] Shan Z(2014)Thyroid physiology in pregnancy Endocr Pract 20 589-768
  • [19] Vural M(2005)Sequential studies on thyroid antibodies during pregnancy Thyroid 15 474-106
  • [20] Koc E(2013)Thyroid autoantibodies in pregnancy: their role, regulation and clinical relevance J Thyroid Res 2013 182472-undefined