Management of Merkel Cell Carcinoma

被引：0
作者：
Herrmann J.L. [1 ]
Yu S.S. [1 ]
机构：
[1] Department of Dermatology, University of California, San Francisco, 1701 Divisadero Street, Third Floor, San Francisco, 94115-0316, CA
来源：
Current Dermatology Reports | 2015年 / 4卷 / 4期
关键词：
Dermatology; Excision; Management; Merkel cell carcinoma; Radiation; Sentinel lymph node biopsy; Skin cancer; Treatment;
D O I：
10.1007/s13671-015-0116-3
中图分类号：
学科分类号：
摘要：
Merkel cell carcinoma is an aggressive neuroendocrine tumor with high rates of local recurrence, micro- and macrometastasis. Its poor prognosis underscores the importance of determining effective treatment protocols. However, given its rarity, there is a paucity of prospective randomized trials to guide evidence-based management. Current guidelines are largely based on retrospective reviews and expert consensus opinion. In general, treatment centers on addressing the primary tumor first, followed by management of nodal and/or metastatic disease. This review discusses therapeutic options by disease stage and highlights where questions remain to be answered. © 2015, Springer Science+Business Media New York.
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收藏
页码：179 / 186
页数：7
相关论文
共 70 条
[1]  
Poulsen M., Merkel-cell carcinoma of the skin, Lancet Oncol, 5, 10, pp. 593-599, (2004)
[2]  
Ogawa H., The Merkel cell as a possible mechanoreceptor cell, Prog Neurobiol, 49, 4, pp. 317-334, (1996)
[3]  
Tang C.K., Toker C., Trabecular carcinoma of the skin: an ultrastructural study, Cancer, 42, 5, pp. 2311-2321, (1978)
[4]  
Allen P.J., Bowne W.B., Jaques D.P., Et al., Merkel cell carcinoma: prognosis and treatment of patients from a single institution, J Clin Oncol, 23, 10, pp. 2300-2309, (2005)
[5]  
Halata Z., Grim M., Bauman K.I., Friedrich Sigmund Merkel and his “Merkel cell”, morphology, development, and physiology: review and new results, Anat Rec A: Discov Mol Cell Evol Biol, 271, 1, pp. 225-239, (2003)
[6]  
Albores-Saavedra J., Batich K., Chable-Montero F., Et al., Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study, J Cutan Pathol, 37, 1, pp. 20-27, (2010)
[7]  
Ellis D.L., Davis R.S., Evidence-based management of primary and localized Merkel cell carcinoma: a review, Int J Dermatol, 52, 10, pp. 1248-1258, (2013)
[8]  
Feng H., Shuda M., Chang Y., Et al., Clonal integration of a polyomavirus in human Merkel cell carcinoma, Science, 319, 5866, pp. 1096-1100, (2008)
[9]  
Bouvard V., Baan R.A., Grosse Y., Et al., Carcinogenicity of malaria and of some polyomaviruses, Lancet Oncol, 13, pp. 339-340, (2012)
[10]  
Coursaget P., Samimi M., Nicol J.T., Et al., Human Merkel cell polyomavirus: virological background and clinical implications, APMIS, 121, 8, pp. 755-769, (2013)
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