Serum levels of bcl-2 in patients with colorectal cancer

被引：4

作者：

Giannoulis K. ^{[1
,2
]}

Fountzilas G. ^{[3
]}

Angouridakis N. ^{[4
]}

Angouridaki C. ^{[4
]}

Giannoulis E. ^{[3
]}

Gamvros O. ^{[2
]}

机构：

[1] 546 22 Thessaloniki

[2] 3rd Department of Surgery, AHEPA University Hospital, Thessaloniki

[3] 1st Department of Medicine, AHEPA University Hospital, Thessaloniki

[4] Laboratory of Serology, AHEPA University Hospital, Thessaloniki

来源：

Techniques in Coloproctology | 2004年 / 8卷 / Suppl 1期

关键词：

Apoptosis; Colorectal cancer; Serum bcl-2;

D O I：

10.1007/s10151-004-0112-2

中图分类号：

学科分类号：

摘要：

Background: Many recent studies focus on the immunohistochemical evaluation of Bcl-2 expression, and its prognostic significance in colorectal cancer (CRC). Our aim was to investigate the presence of bcl-2 protein in the serum and to examine the association between its levels, stage and tumour load, in patients with CRC. Methods: A commercially available ELISA was used for the estimation of bcl-2 levels, in 94 patients with different stages of CRC. Forty-eight healthy blood donors served as controls. Concentrations ranging 2SD above and below the controls median were accepted as "normal". Results: bcl-2 was detected in the serum of patients with CRC. A significantly higher proportion of patients with non-metastatic disease (61%), had high serum bcl-2 values, compared to patients with metastatic disease (28%, p<0.0001). Conclusions: Serum bcl-2 in patients with CRC may reflect the degree of Bcl-2 expression in cancer tissue. Serum bcl-2 is easily determinable, and could be useful as a prognostic marker in CRC.

引用

页码：S56 / S58

页数：2

共 7 条

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