Synthesis of a Highly Potent Antitumor Saponin OSW-1 and its Analogues

被引：31
作者：
Jacek W. Morzycki
Agnieszka Wojtkielewicz
机构：
[1] University of Bialystok,Institute of Chemistry
来源：
Phytochemistry Reviews | 2005年 / 4卷 / 2-3期
关键词：
antitumor activity; cholestane glycosides; OSW-1; saponins; steroids;
D O I：
10.1007/s11101-005-1233-6
中图分类号：
学科分类号：
摘要：
Twelve years ago a group of cholestane glycosides was isolated from the bulbs of Ornithogalum saundersiae, a species of the lily family without any medicinal folklore background. Similar glycosides were recently isolated from Galtonia candicans. The major component of the mixture of saponins, OSW-1, exhibited sub-nanomolar antineoplastic activity. While OSW-1 is exceptionally cytotoxic against various tumor cells, it shows little toxicity with normal human pulmonary cells. In this review article the synthetic efforts towards OSW-1 and related cholestane glycosides, as well as the preliminary results of the structure–activity relationship study are presented.
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页码：259 / 277
页数：18
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