Stem cell function and maintenance – ends that matter: Role of telomeres and telomerase

被引：0
作者：
Hamid Saeed
Mehwish Iqtedar
机构：
[1] Stanford University,Department of Endocrinology, School of Medicine
[2] Lahore College for Women University,Department of Bio
来源：
Journal of Biosciences | 2013年 / 38卷
关键词：
Aging; stem cells; telomerase; telomeres;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Stem cell research holds a promise to treat and prevent age-related degenerative changes in humans. Literature is replete with studies showing that stem cell function declines with aging, especially in highly proliferative tissues/organs. Among others, telomerase and telomere damage is one of the intrinsic physical instigators that drive age-related degenerative changes. In this review we provide brief overview of telomerase-deficient aging affects in diverse stem cells populations. Furthermore, potential disease phenotypes associated with telomerase dysregulation in a specific stem cell population is also discussed in this review. Additionally, the role of telomerase in stem cell driven cancer is also briefly touched upon.
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页码：641 / 649
页数：8
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