Effect of Different Iodine Concentrations on Well-Differentiated Thyroid Cancer Cell Behavior and its Inner Mechanism

被引：0
作者：
Jun Xiang
Xuemei Wang
Zhuoying Wang
Yi Wu
Duanshu Li
Qiang Shen
Tuanqi Sun
Qing Guan
Yunjun Wang
机构：
[1] Fudan University,Department of Head and Neck Surgery, Shanghai Cancer Center (FUSCC)
[2] Fudan University,Department of Oncology, Shanghai Medical College
[3] Obstetrics and Gynecology Hospital of Fudan University,Department of Ultrasound
来源：
Cell Biochemistry and Biophysics | 2015年 / 71卷
关键词：
High iodine intake; Thyroid cancer; Thyroid carcinoma; Iodine concentration on cell behavior; Akt; Erk; Cytokine VEGF-A;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
High iodine intake might be an important factor in the promotion of thyroid cancer and the incidence of thyroid carcinoma has increased obviously these years especially in area of high iodine intake, though the mechanism of which remains unknown. The aim of present study was to gain more insight into the influence of different iodine concentrations on cell behavior, such as proliferation and migration, and to further investigate its molecular mechanism using two well-differentiated thyroid cancer cell lines. Our study evaluated the effect of different iodine concentrations on cell behavior and investigated relevant molecules involved. The results indicated that iodine in vitro could promote the growth of thyroid cancer cells with the increase of iodine concentration in a specific range. Such effect may be related to signaling pathways as Akt and Erk and cytokine VEGF-A.
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页码：299 / 305
页数：6
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