Lentivirus-mediated transfection of chondroitinase ABC gene without the bacterial leader sequence enables long-term secretion of functional chondroitinase ABC in human bone marrow stromal cells

被引:0
作者
Yang Guo
Michael Klüppel
Hao Tang
Sheng Tan
Peidong Zhang
Zhenzhou Chen
机构
[1] Southern Medical University,Department of Neurology, Zhujiang Hospital
[2] Northwestern University,Department of Pediatrics, Robert H. Lurie Comprehensive Cancer Center, Stanley Manne Children’s Research Institute
[3] Medical University,Department of Cardiovascular Medicine, Zhujiang Hospital, Southern
[4] Southern Medical University,Department of Neurosurgery, National Key Clinic Department, Zhujiang Hospital
来源
Biotechnology Letters | 2016年 / 38卷
关键词
Chondroitinase ABC; Bone marrow stromal cells; Lentivirus; Secretion; Chondroitin sulfate proteoglycans;
D O I
暂无
中图分类号
学科分类号
摘要
引用
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页码:893 / 900
页数:7
相关论文
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  • [1] Bradbury EJ(2002)Chondroitinase ABC promotes functional recovery after spinal cord injury Nature 416 636-640
  • [2] Moon LD(2007)Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans J Neurosci 27 2176-2185
  • [3] Popat RJ(2014)Regulation of IL-10 by chondroitinase ABC promotes a distinct immune response following spinal cord injury J Neurosci 34 16424-16432
  • [4] King VR(2013)Evidence for high translational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke J Cereb Blood Flow Metabol 33 1322-1334
  • [5] Bennett GS(2011)Efficient secretion of biologically active chondroitinase ABC from mammalian cells in the absence of an Mol Cell Biochem 351 1-11
  • [6] Patel PN(2005)-terminal signal peptide Neuroreport 16 1763-1767
  • [7] Fawcett JW(2008)Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice Restor Neurol Neurosci 26 131-145
  • [8] McMahon SB(2010)Proteoglycans in the central nervous system: plasticity, regeneration and their stimulation with chondroitinase ABC Stem Cells 28 1099-1106
  • [9] Cafferty WB(2013)A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke Biochim Biophys Acta 1830 4719-4733
  • [10] Yang SH(2014)Biosynthesis and function of chondroitin sulfate J Neurotrauma 31 803-818