Epidermal growth factor receptor and glioblastoma multiforme: molecular basis for a new approach

被引:0
作者
Cristóbal Belda-Iniesta
Javier de Castro Carpeño
María Sereno
Manuel González-Barón
Rosario Perona
机构
[1] University Hospital La Paz,Translational Oncology Unit (CSIC/UAM) at Medical Oncology Division
[2] Universidad Autonoma de Madrid,Medical Oncology Division
[3] MD Anderson Cancer Center International,undefined
[4] Translational Oncology Unit (CSIC/UAM) at Biomedical Research Institute “Alberto Sols”,undefined
来源
Clinical and Translational Oncology | 2008年 / 10卷
关键词
EGFr; Gliomas; Tyrosine kinase; PTEN; AKT;
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摘要
High-grade gliomas are the most common primary malignant brain tumours. Surgery, radiotherapy and chemotherapy are the cornerstone of actual treatment. In spite of large therapeutic efforts, overall survival is still poor. New molecular data allow a new molecular classification for high-grade gliomas and open a therapeutic window for targeted therapy. Molecular diagnostic tools may provide a basis for receptor-based therapies and enough information to personalise future treatments. In this regard, epidermal growth factor receptor (EGFR) is a target that will play a critical role in the management of glioma patients. This review summarises basic and preclinical data that support future use of therapies against EGFR.
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