Tourette syndrome: Gene expression as a tool to discover drug targets

被引：0
作者：
Isaac H. Liao
Frank R. Sharp
机构：
[1] University of California at Davis,Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute and Department of Neurology
来源：
Neurotherapeutics | 2010年 / 7卷
关键词：
Tourette syndrome; gene expression; microarrays; pharmacology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Gene expression microarrays are a high-throughput, cost-effective method for measuring the expression of all genes in a sample. By comparing the expression patterns of healthy controls to diseased subjects, the genetic regulatory pathways underlying and affected by the disease can be elucidated. Furthermore, dysregulated genes are possible candidates for pharmaceutical therapy. Here, we consider the possibility of applying this approach to Tourette syndrome. We also review current theories of Tourette syndrome etiology and pharmacology.
引用
收藏
页码：302 / 306
页数：4
相关论文
共 178 条
[1]  
Swain JE(2007)Tourette syndrome and tic disorders: a decade of progress J Am Acad Child Adolesc Psychiatry 46 947-968
[2]  
Scahill L(2007)Tourette’s syndrome: clinical features, pathophysiology, and therapeutic approaches Dialogues Clin Neurosci 9 161-171
[3]  
Lombroso PJ(2005)Tourette’ s syndrome: from behaviour to biology Lancet Neurol 4 149-159
[4]  
King RA(2007)What’s wrong with Tourette syndrome? Parkinsonism Relat Disord 13 S385-S386
[5]  
Leckman JF(1991)A family study of Gilles de la Tourette syndrome Am J Hum Genet 48 154-163
[6]  
Müller N(2001)A family study of Tourette syndrome in Japan Am J Med Genet 105 414-421
[7]  
Singer HS(1996)Family study and segregation analysis of Tourette syndrome: evidence for a mixed model of inheritance Am J Hum Genet 59 684-693
[8]  
Kremer HPH(1997)Rates for tic disorders and obsessive compulsive symptomatology in families of children and adolescents with Gilles de la Tourette syndrome J Psychiatr Res 31 519-530
[9]  
Pauls DL(1993)Evidence for autosomal dominant transmission in Tourette’s syndrome. United Kingdom cohort study Br J Psychiatry 162 593-596
[10]  
Raymond CL(1985)A twin study of Tourette syndrome Arch Gen Psychiatry 42 815-820
12345678910