Modification and clearance of low density lipoproteins during the formation of endotoxin-lipoprotein complexes

被引：0

作者：

Ya. Sh. Schvartz

L. M. Polyakov

M. I. Dushkin

E. N. Pivovarova

机构：

[1] Siberian Division of Russian Academy of Medical Sciences,Institute of Therapy

[2] Siberian Division of Russian Academy of Medical Sciences,Institute of Biochemistry

来源：

Bulletin of Experimental Biology and Medicine | 2008年 / 145卷

关键词：

bacterial lipopolysaccharides; low density lipoproteins; lipopolysaccharide-low density lipoprotein complexes;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Changes in electrical charge and clearance rate of LDL after the formation of their complexes with bacterial LPS were studied in experiments on Wistar rats. It was found that binding of S. minnesota R595 LPS with 125I-LDL sharply accelerated clearance of the greater part of LDL complexes, but on the other hand induced the appearance of an LDL-LPS subfraction with slower elimination rate compared to free LDL. Electrophoresis showed that after binding of LPS, LDL acquired a negative charge. These data suggest that the formation of LDL-LPS complexes is accompanied by modification of LDL due to which they acquire atherogenic properties.

引用

页码：430 / 432

页数：2

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