P2Y6 receptor and immunoinflammationP2Y6受体与免疫炎症

被引：0
作者：
Gui-Dong Liu
Jian-Qing Ding
Qin Xiao
Sheng-Di Chen
机构：
[1] Ruijin Hospital Affiliated to Shanghai Jiaotong University,Department of Neurology and Institute of Neurology
[2] School of Medicine,undefined
来源：
Neuroscience Bulletin | 2009年 / 25卷
关键词：
purinoceptor P2Y6; microglia; inflammation; immunology; neurodegeneration; P2Y6受体; 小胶质细胞; 炎症; 免疫; 神经退行性疾病; Q421; R749;
D O I：
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中图分类号：
学科分类号：
摘要：
The immunocytes microglia in the central nervous system (CNS) were reported to play a crucial role in neurodegeneration. As a member of P2 receptors family, purinoceptor P2Y6 has attracted much attention recently. Previous studies showed that purinoceptor P2Y6 mainly contributed to microglia activation and their later phagocytosis in CNS, while in immune system, it participated in the secretion of interleukin (IL)-8 from monocytes and macrocytes. So there raises a question: whether purinoceptor P2Y6 also takes part in neuroinflammation? Thus, this review mainly concerns about the properties and roles of purinoceptor P2Y6, including (1) structure of purinoceptor P2Y6; (2) distribution and properties of purinoceptor P2Y6; (3) relationships between purinoceptor P2Y6 and microglia; (4) relationships between purinoceptor P2Y6 and immunoinflammation. It’s proposed that purinoceptor P2Y6 may play a role in neuroinflammation in CNS, although further research is still required.
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页码：161 / 164
页数：3
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