Caspases in synaptic plasticity

被引：0
作者：
Zheng Li
Morgan Sheng
机构：
[1] National Institute of Mental Health,Unit on Synapse Development and Plasticity
[2] National Institutes of Health,Department of Neuroscience
[3] Genentech Inc,undefined
来源：
Molecular Brain | / 5卷
关键词：
Synaptic Plasticity; AMPA Receptor; Dendritic Spine; Initiator Caspases; Mitochondrial Apoptotic Pathway;
D O I：
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学科分类号：
摘要：
Caspases are a family of cysteine proteases that play key roles in programmed cell death (apoptosis). Mounting evidence in recent years shows that caspases also have important non-apoptotic functions in multiple cellular processes, such as synaptic plasticity, dendritic development, learning and memory. In this article, we review the studies on the non-apoptotic functions of caspases in neurons, with a focus on their roles in synaptic plasticity, learning and memory and neurodegeneration.
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